The Division of Medicinal Chemistry

Spring 1999 Newsletter

D. Amy Trainor - Secretary

Candidates for Election to Division Offices

A Nominating Committee composed of three members of the Division was formed to identify a list of candidates for election. In accordance with Division Bylaws the membership of this committee remains anonymous. Their selection of candidates is as follows:

William Greenlee, Schering-Plough Research Institute (Vice-Chair)
Jill Panetta, Eli Lilly (Vice-Chair)
One to be elected

Thomas J. Perun, Abbott Laboratories (Industrial Councilor)
Mark Murcko, Vertex (Industrial Councilor)
One to be elected

Daniel H. Rich, University of Wisconsin-Madison (Academic Councilor)
Duane D. Miller, University of Tennessee-Memphis (Academic Councilor)
One to be elected

B.K. Trivedi, Parke Davis (Treasurer)
One to be elected

Ballots will be sent to all members shortly.

The other officers of the Division for 1999, as previously elected are listed below:

Annette M. Doherty, Chair
Jane Aldrich, Vice-Chair
D. Amy Trainor, Secretary
Leslie G. Humber, Treasurer
Gary Grunewald, Councilor
James R. McCarthy, Councilor
Michael F. Rafferty, Councilor
Leroy B. Townsend, Councilor
Kenneth Kirk, Past Chair

Membership Committee Report

Based on data provided by ACS, divisional membership as of 12/31/98 is 8176. This represents an increase of 500 since the end of 1997. Note that this number included all categories of members, including unpaid. Thde Chair of the Membership Committee is David P. Rotella.

218th American Chemical Society Meeting, New Orleans, LA, August 22-26, 1999.

The final program for the Medicinal Chemistry Division is outlined below. Recipients of the Division Graduate Fellowships will present their research at a symposium to be held on Wednesday morning. There will be several general oral and poster sessions and the detailed final program will be available in an upcoming issue of C and E News, as well as the Division Homepage on the World Wide Web.

New Orleans, Fall 1999 Program
Symposium Title (Organizer/Chair)

Sun AM - General Oral Papers (A. Trainor)
Sun PM - General Oral Papers (A. Trainor)
Sun PM - Combinatorial Chemistry (J. Ellman/J. Falck)
Sun EVE - General Poster Session (A. Trainor)
Mon AM - Smissman Award Symposium (A. Doherty)
Mon PM - Pharmacokinetics (E. Kyburz)
Tues AM - Addiction (K. Cooper/K. Janda)
Tues AM - General Oral Papers (A. Trainor)
Tues PM - Serotonin Receptor Modulators (A. Robichaud)
Wed AM - Fellowship Awards Symposium (A. Trainor)
Wed AM - Agonist/Antagonist Pairs (K. Shiosaki)
Wed PM - Antibiotic Resistance - Vancomycin and Beyond (J. Schwab/J. Ellman)
Wed All - Co-Running Poster Session (A. Trainor)
Thurs AM - Cell Cycle (A. Doherty)
Thurs PM - Biotechnology in Medicine (A Christianson)

219th American Chemical Society Meeting, San Francisco, CA, March 26-30, 2000.

Call for Papers

Program Chair and Secretary:
D. A. Trainor
Zeneca Pharmaceuticals,
1800 Concord Pike
Wilmington DE
19850-5437
Voice: (302) 886-2666
FAX: 302 886-4726
E-mail: amy.trainor @phwilm.zeneca.com

One copy of 150-word original abstract on ACS Abstract Form is due to Program Chair for all sessions by October 8, 1999. The Online Abstract Submittal System (OASys) is now available for instant submissions at www.acs.org/meetings. If you do not have Internet access, forms are also available from the Membership Service Center at (800) 227-5558. Hardcopy submittals due to Program Chair by October 8, 1999. A 1,000-word expanded abstract or equivalent supporting documentation is required for general oral presentations (not for invited speakers or poster presenters). Please send the expanded abstract to the Program Chair by October 15, 1999.

AMPA and NMDA Receptor Agents (Co-Run)
J. Monn, Eli Lilly & Co., Lilly Corporate Center, Drop Code 510, Bldg. 48, C1109, Indianapolis IN 46285, (317) 276-9202, fax (317) 276,7600, E-mail: monn_james_2@lilly.com
J. Wright, Parke-Davis Pharmaceutical Research, 2800 Plymouth Road, Ann Arbor MI 48105

General Oral Papers.
A. Trainor, Zeneca Pharmaceuticals, 1800 Concord Pike, Wilmington, DE 19850-5437, (302) 886-2666, fax 302 886-4726, E-mail: amy.trainor@phwilm.zeneca.com

Posters.
A. Trainor, Zeneca Pharmaceuticals, 1800 Concord Pike, Wilmington, DE 19850-5437, (302) 886-2666, fax 302 886-4726, E-mail: amy.trainor@phwilm.zeneca.com

Drug Delivery Techniques in the New Millennium.
K. Shiosaki, Millennium Pharmaceuticals, One Kendall Square, Building 300, Cambridge MA 02139, (617) 761-6890, fax (617) 225-2997, E-mail: shiosaki@mpi.com

New Advances in Protein Tyrosine Phosphatase Inhibitors.
K. Shiosaki, Millennium Pharmaceuticals, One Kendall Square, Building 300, Cambridge MA 02139, (617) 761-6890, fax (617) 225-2997, E-mail: shiosaki@mpi.com

Award Symposium.
A. Trainor, Zeneca Pharmaceuticals, 1800 Concord Pike, Wilmington, DE 19850-5437, (302) 886-2666, fax 302 886-4726, E-mail: amy.trainor@phwilm.zeneca.com

Process Research in the Pharmaceutical Industry.
T. Kaneko, Pfizer Central Research, Eastern Point Road, Groton CT 06340, (860) 441-5393, fax (860) 441-4111, E-mail: takushi_kaneko@groton.pfizer.com

Case Studies: Overcoming Hurdles in Drug Development.
B.K. Trivedi, Parke-Davis Pharmaceutical Research, 2800 Plymouth Road, Ann Arbor MI 48105, (734) 622-7709, fax (734) 622-3107, E-mail: TRIVEDIB@AA.WL.COM

Protein Therapeutics.
G. Ellestad, Wyeth-Ayerst Research Laboratories, Pearl River NY 10965, (914) 732-4294

Selective Estrogen Receptor Modulators /Osteoporosis.
J. Monn, Eli Lilly & Co., Lilly Corporate Center, Drop Code 510, Bldg. 48, C1109, Indianapolis IN 46285, (317) 276-9202, fax (317) 276,7600, E-mail: monn_james_2@lilly.com

G. Ellestad, Wyeth-Ayerst Research Laboratories, Pearl River NY 10965, (914) 732-4294, fax (914) 732-5536, E-mail: ellestg@war.wyeth.com

Chemokine Antagonists as Anti-inflammatory and Antiviral Agents.
J. McCarthy, Medicinal Chemistry, Neurocrine Biosciences, 3050 Science Park Road, San Diego CA 92121-1102, (619) 658-7630, fax (619) 658-7696, E-mail: jim_mccarthy@neurocrine.com

New Perspectives in Anticancer Agents.
I. Ojima, Dept. Of Chemistry, State University of New York at Stony Brook, Stony Brook, NY 11794-3400, (516) 632, 7890, fax (516) 632-7942, E-mail: IOJIMA@notes.cc.sunysb.edu

Predoctoral Fellowship Awards

Five $20,000 fellowships have been awarded to students in graduate programs engaged in medicinal chemistry research. A number of applications were reviewed by a committee of experts from both Academia and Industry. The sponsoring companies are: Abbott, Bristol-Myers Squibb, Hoechst-Marion Roussel, Wyeth-Ayerst, Parke-Davis. The recipients and mentors are:

Jennifer J. Kohler (Alanna Schepartz) Yale University
Brenda Nieslanik (William M. Atkins) University of Washington
L. Nathan Tumey (Michael C. Pirrung) Duke University
Ryan M.Van Wagoner (Chris M. Ireland) University of Utah
Maha Zewail-Foote (Laurence H. Hurley) University of Texas

Congratulations to the winners of these awards! We also thank the other applicants for the excellent proposals which were submitted.

2000-2001 Predoctoral Fellowships

The ACS Division of Medicinal Chemistry announces the continuation of its Fellowship program. Five $20,000 fellowships will be awarded in 2000, through the sponsorship of the following companies: Abbott Laboratories, Bristol-Myers Squibb, Hoechst-Marion Roussel, Parke-Davis Pharmaceutical Research, and Wyeth-Ayerst Research. The awards are for predoctoral students engaged in medicinal chemistry research in a Medicinal Chemistry, Pharmaceutical Chemistry, Biochemistry, or Chemistry department listed in the current ACS Directory of Graduate Research.

Nominations should include a complete student curriculum vitae, including education and work experience; a student bibliography, including reprints of articles; a complete project description including rationale (five-page limit) prepared by the candidate; transcripts of all post-high school work, including Graduate Record Examination scores (if available); three letters, including a nomination letter from the student's research advisor; and a letter from a university official with a commitment to cover tuition and all fees granted to other regular graduate students.

Applicants must be U.S. citizens or permanent resident visa holders at the time of application and must have at least one year of graduate school remaining at the time an award would begin September 1, 2000. Additional information (including a complete set of guidelines) can be obtained from Dr. Annette Doherty, Ph.D., Institut de Recherche Jouveinal, 3-9 rue de la Loge, BP 100, 94265 Fresnes, Cedex, France, phone 33-1-41-96-7578, Fax 33-1-40-96-7559, E-mail: annette.doherty@wl.com.

All application materials for the awards are due on January 15, 2000 and must be received by Dr. Annette Doherty (2000 Past Chair) at the above address.

ACS Division of Medicinal Chemistry WWW Update

The World Wide Web site for the Division of Medicinal Chemistry continues to expand. The Division WWW page URL is: http://wiz2.pharm.wayne.edu

The page now has an updated graphic interface where users select topics by clicking on buttons on a site map. One of the sections on this map is a What's New section for late-breaking announcements. A new, more reliable hit counter was installed on February 17, 1999. The page now receives over 2000 hits per month, a substantial increase over the usage of two years ago. The Division homepage is clearly becoming the method of choice for access to Division news and information. Coming Soon: ACSMEDI Public Domain Software Archive.

The ACS Division of Medicinal Chemistry On-Line Employment Service The ACSMEDI virtual "job service" located at http://wiz2.pharm.wayne.edu/employ.html and accessible from the main page has been very popular. There are currently 4 academic, 24 industrial, 2 government and 15 postdoctoral ads posted on this site. A link to the Organic Division employment site is also provided. Division members may post ads to the employment section in any of the four sections by forwarding the text of the position announcement and any associated graphics by email to Pat Woster at woster@wizard.pharm.wayne.edu.

The ACS Division of Medicinal Chemistry One-Stop Meeting Registration Page There is now a section on our homepage that allows Division members to register for National ACS meetings, and to submit abstracts electronically from a "one stop" page. This section of the Division homepage is located at http://wiz2.pharm.wayne.edu/register.html and is accessible from the main page.

Schedule of ACS National Meetings

218th National Meeting, Fall 1999, August 22-26, New Orleans, LA
219th National Meeting, Spring 2000, March 26-31, San Francisco, CA
220th National Meeting, Fall 2000, August 20-25, Washington, D.C.
221st National Meeting, Spring 2001, April 1-5, San Diego, CA

Division of Medicinal Chemistry Travel Grants

The Division of Medicinal Chemistry makes available 14 grants annually of $600 each to aid young chemists in presenting papers at the ACS National Meetings.

The applicant must be an ACS member (student or affiliate) and not have previously been the recipient of this award. Each university department can have only one awardee.

In order of priority, the following criteria will be used for selection of awards: Graduate Students, Postdoctoral Fellow, Individual with less than five years post-Ph.D. experience. Scientific merit of paper to be presented will also be considered.

Send applications to Amy Trainor, AstraZeneca Pharmaceuticals, 1800 Concord Pike. Wilmington, DE 19850-5437, USA by October 15, 1999.

Awardees will be notified of the granting of such an award in sufficient time so that the awardee can pre-register for the meeting. The awards will be made at the Sunday evening business meeting of the Division.

APPLICATION FORM TO BE SUBMITTED WITH ABSTRACT

1. Name of Applicant for Travel Grant ____________________________________.
2. Degree __________ Year Obtained:___________________
3. Present Institution:______________________________________
4. Department:________________________________________________________
5. Work to be reported was (check one or more):

a. Ph.D. Thesis ___________
b. M.S. Thesis ___________
c. Postdoctoral Fellowship ___________
d. Supported by:
1. Grant___________
2. Department ___________
3. Other__________________________________

Nominations for the 2000 Division of Medicinal Chemistry Award

Nominations are being sought for the 2000 Division of Medicinal Chemistry Award. This award is open to any scientist or team of scientists whose research has, directly or indirectly, had a significant effect on medicinal chemistry. Although other types of accomplishment (such as a new research tool or a biological discovery) will not be excluded, emphasis shall be place on (a) medicinal chemistry, (b) recent contributions, and (c) scientists whose accomplishments have not already been adequately recognized in the form of other honors. The recipients of this award since 1980 are: C.R. Ganellin, B. Samuelsson, P.A.J. Janssen, R. Hirschmann, G. Marshall, P. Portoghese, D.H. Rich, L.H. Hurley, K. Rice and J. Topliss.

Nomination must include a letter of nomination, a seconding letter (optional but highly recommended) and a recent CV of the nominee. Materials must be received by September 15, 1999. Nominees are encouraged to contact Dr. Vacca, Chair of the Awards Nominating Committee, before submission. Dr. Vacca's address is:

Dr. Joseph Vacca
Merck Research Laboratories
WP26-410
West Point PA 19486-0004
Phone 215 652-7439
Fax 215 652-3971
E-mail: joe_vacca@merck.com

Journal of Medicinal Chemistry Perspective Series

The Perspective series of the Journal of Medicinal Chemistry is designed to provide an enlightened appraisal of a field of research in which recognized experts review the state-of-the-art for a given area or therapeutic target. Authors have some editorial freedom to express their perspective on the strategic directions of the field of research. As such, the Perspective series is a forum that achieves high visibility within the pharmaceutical industry and academia.

We are attempting to commission a number of high-quality manuscripts to ensure that at least one Perspectives article is published every month. We would like the series to be useful to a broad range of scientists interested in the design, discovery and development of novel medicines.

We welcome your input regarding topics and authors for Perspectives manuscripts. Please direct correspondence or calls regarding the series to:

David W. Robertson, Ph.D.
DuPont Pharmaceuticals Co.
Experimental Station, Bldg. 500
Route 141
Wilmington, DE 19880-0500
Tel: 302-695-4513
Fax: 302-695-4390

2000 National Medicinal Chemistry Symposium

SPONSORED BY

Division of Medicinal Chemistry,
American Chemical Society

HOSTED BY

Department of Medicinal Chemistry,
University of Kansas

SYMPOSIUM TOPICS

Recent Advances in Phosphatase Inhibition - Zhong Zhang, Albert Einstein College of Medicine, chair
New Serine and Cysteine Non-covalent Protease Inhibitors -Dan Veber, SmithKline Beecham, chair
Amyloid Precursor Protein Processing/Secretases - Jim Audia, Eli Lilly, chair
Parallel Array Synthesis Methods - Dale Boger, Scripps Research Institute, chair
Special Topics in Organic Synthesis - Gunda Georg, University of Kansas, chair
ATP Competitive Kinase Inhibition - Alex Bridges, Parke Davis, chair

AWARD ADDRESS

Recipient of the 2000 Division of Medicinal Chemistry Award

GENERAL CHAIR

Gary L. Grunewald, University of Kansas
E-mail: ggrunewald@ukans.edu

PROGRAM CO-CHAIRS

Michael Rafferty, Parke Davis
E-mail: raffe01@aa.wl.com

Daniel Flynn, Amgen
E-mail: dflynn@amgen.com

FURTHER INFORMATION

www.pharm.ukans.edu/nmcs
E-mail: phicks@ukans.edu
phone: 913/897-8522
fax: 913/897-8540

Other Meetings of Interest

2002 Medicinal Chemistry Symposium

There appears to be a strong preference for a West Coast location. If you are interested in proposing a location (west coast or other) and are willing to organize this symposium, please contact Annette Doherty.

AIMECS 1999 Beijing, China

Tom Perun will be representing the Division as a member of the organizing committee. Ken Kirk and Les Mitscher will be giving presentations at this meeting on fluorinated adrenergic probes and chemical libraries respectively.

Year 2000 ACS Meetings

The committee on Divisional Activities has agreed to coordinate a consolidated effort to develop special programming to celebrate the "Turn of the Century" at the spring 2000 National Meeting in San Francisco. The proposal for this event was developed and brought forward by several current and past Division chairs. Peter Haustein (NUCL), George Famini (COMP), Robin Rogers (I&EC) and Chris Pruit, Administrator of the ACE meeting Department. A steering committee has been established to coordinate this ACS wide effort and Dr. Paul S. Andersen, immediate past President of the society, has agreed to chair this committee. The first meeting was held June 7/8, 1998 and they discussed divisional symposia that could contribute to this event. Each division is being asked to contribute at least _ day session to support this initiative, which is directly related to impact of the field (Med. Chem) in the 21st century.

Ideas to date from the committee have included, helping the environment, global chemistry and sustainable technologies. There will be a plenary session concerning "Evolution of chemical enterprise in the 21st century", For the general public there will be a plenary session on "Quality of life - 21st century".

XVI International Symposium on Medicinal Chemistry - Bologna, September 2000

Inaugural lecturer: Dan Rich (USA)

4 Plenary Lectures:

'Current status of the adrenoceptors and their subtypes: relationship to cardiovascular disease' by R.R. Ruffolo (USA)
New Technologies (D. Donati)
Apoptosis (F. Gualtier)
Pain (D. Donati)

Invited Lectures:

Cardiovascular Agents
Antihypertesives (A. Leonardi)
Hypolipaemics/Antiatherosclerotics (D. Buckle)
Antiviral Agents (J. Rodgers)
Anticancer Agents (Mongelli, Palumbo)
Pharmacokinetic Lead Optimisation (B. Testa)
New Technologies (D. Donati)
P1 and P2 Purinergic Receptors (P. G. Baraldi)
The Impact of Chemistry in Drug Discovery (C. Chatgilialoglu)
Neurodegenerative diseases (F. Gaultieri, E. Kyburz)
Aminoacid Receptors:
GABA (Froestl)
Ionotropic Glutamate Receptors (R. Pellicciari)
Antiinflammatory Agents (B. Macchia)
Antiinfective Agents (AFMC)
New Paradigms in Receptorology (H. Timmermann)
Polyamines as Templates for Transmitter Receptor Ligands (P. Usherwood)
Natural Products (K. J. Wright, ACS)
Pain: Bennett (D. Donati)

4TH International Symposium on Medicinal Chemistry of Neurodegenerative Diseases Marriott CasaMagna, Mexico, January 30 - February 2, 2000

This Fourth International Symposium will convene to present recent advances in the medicinal chemistry of agents targeted for the treatment of neurodegenerative diseases. The first meeting in this series was held in 1993 with an Alzheimer's Disease emphasis and this symposium has been expanded to cover a wider range of neurodegenerative disorders. For complete program information, click HERE

International Chemical Congress of Pacific Basin Societies - December 14-19, 2000

Pacifichem 2000 will be held from December 14-19, 2000 in Honolulu, Hawaii. The program will feature extensive programming in the Medicinal Chemistry subject area including Symposia on the following topics:

Chemistry and Signal Transduction
Neurochemistry of Excitatory Amine Acids
Molecular Recognition Using Nucleic Acids and Their Related Substances
Recent Advances in Protease Inhibitor Design
Mathematical and computational Aspects of
Molecular Design
Viral Serine Proteases
Cysteine Proteases
Advances in Radiopharmaceutical Chemistry
Alzheimer's Disease: Receptors and Small Molecule Therapies
Radionuclides for Therapeutic Oncology
Frontiers in Antibiotics: Synthesis, Design and Mode of Action
Next Generation Therapeutics
Matrix Metalloproteinase Inhibitors (tentative)

There will also be extensive programming in related subject areas; Organic chemistry (26 Symposia) and Bioscience and Technology (18 Symposia). The deadline for the submission of abstracts for contributed papers is April 14, 2000. For information on Pacifichem see: http://www.acs.org/meetings/pacific/welcome.htm

33RD Middle Atlantic Regional Meeting of the American Chemical Society

The 33rd MARM will be held May 15-17, 2000 at the Clayton Hall Conference Center at the University of Delaware in Newark DE. The central organizing theme for technical programming will be "Accelerating Drug Discovery and Development". For comprehensive information on MARM 200 see: http://www.dca.net/marm2000/

Millennium Conference on Nucleic Acid Therapeutics

A broad international research effort to develop DNA and RNA analogs as therapeutics for cancers, chronic diseases, and microorganisms has finally lead to clinical trials and the first FDA approval of a DNA drug. Great progress has occurred since the last Clearwater Beach meeting in 1991. The 2000 meeting will provide a forum whereby the most recent developments in preparing gene specific drugs and vectors, and applying those agents in preclinical and clinical trials will be shared among scientists.

The conference will be held January 8-11, 2000 at the Hilton Clearwater Beach Resort in Clearwater Beach FL. Participants will be limited to 300. Six sessions are currently planned, with six talks in each session. Additional speakers for each session will be selected from submitted abstracts.

Sunday morning - Oligonucleotide Derivatives
Sunday evening - Diagnostic Oligonucleotide Chips
Monday morning - Mechanisms and Pharmacology
Monday evening - Preclinical trials
Tuesday morning - Gene Therapy Vectors
Tuesday evening - Clinical trials

Register at the conference website:

http://tesla.jci.tju.edu/millennium.html

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