The Division of Medicinal Chemistry

Fall 1999 Newsletter

D. Amy Trainor - Secretary

The ACS Division of Medicinal Chemistry Homepage

The World Wide Web homepage for the Division of Medicinal Chemistry, located at http://wiz2.pharm.wayne.edu, continues to expand. The page has an easy-to-use graphic interface where users select topics by clicking buttons on a site map. One of the sections on this map is a What's New section for late-breaking announcements. There is also an Employment section for posting open academic, industrial, government and postdoctoral opportunities in Medicinal Chemistry. A new, more reliable hit counter was installed, and indicates that the page receives over 2000 hits per month. The Divison homepage is clearly becoming the method of choice for access to Division news and information.

Election of Division Officers

The results of the election of Division Officers are as follows:

Vice Chair: William Greenlee, Schering-Plough Research Institute
Industrial Councilor: Thomas J. Perun, Protarga, Inc.
Academic Councilor: Daniel H. Rich, University of Wisconsin-Madison
Treasurer: B.K. Trivedi, Parke Davis

The terms of office for the electees will begin in January of 2000. Congratulations to all of the winners!

The previously elected Division officers for 2000 are listed below:

Jane Aldrich, Chair
D. Amy Trainor, Secretary
Gary Grunewald, Councilor
James R. McCarthy, Councilor
Annette Doherty, Past Chair

Upcoming Awards

Dr. Philip S. Portoghese named recipient of the 2000 Alfred Burger Award in Medicinal Chemistry

Dr. Philip S. Portoghese has been named recipient of the 2000 Alfred Burger Award in Medicinal Chemistry for outstanding contributions to the field of Medicinal Chemistry, and in particular, for research on the molecular recognition of ligands at opioid receptors, for his leadership over the past 27 years as Editor-in-Chief of the Journal of Medicinal Chemistry.

The Alfred Burger Award in Medicinal Chemistry is sponsored by SmithKline Beecham. The purpose of the award is to recognize outstanding contributions to research in medicinal chemistry. The award consists of $3,000 and a certificate. Travel expenses to the meeting at which the award will be presented are paid. The award will be presented biennially in even-numbered years and the recipient shall present an award address at the spring meeting of the Division of Medicinal Chemistry The award was established in 1978 by SmithKline Corporation.

Division Awards

Lester A. Mitscher Named 11th Recipient of the Division of Medicinal Chemistry Award

Dr. Les Mitscher is University Distinguished Professor of Medicinal Chemistry at the University of Kansas and he will receive the award at the upcoming 27th National Medicinal Chemistry Symposium in Kansas City, Missouri June 13-17, 2000. The award was established in 1979 to recognize outstanding achievement in the sciences that contribute to the field of medicinal chemistry. Previous winners are: C. R. Ganellin, B. Samuelsson, P. A. J. Janssen, R. Hirschmann, G. Marshall, P. Portoghese, D.H. Rich, L. H. Hurley, K. Rice and J. Topliss. He is best known for his work in natural product chemistry, which ranges from the development and popularization of the use of circular dichroism for structural elucidation to the isolation of novel entities using bioassay-guided fractionation. He has mostly specialized in the search for new antimicrobial agents and was a key player in the development of both tetracycline- and quinolone-based agents. Perhaps the highest-profile example of his work in this area has been the isolation of novel antioxidants from green tea. This work has attracted intense interest from the profession as well as the lay press. His service as a teacher and mentor extend even beyond his outstanding work with young scientists at Ohio State and the University of Kansas. He is a co-founder of the Drew University Residential School on Medicinal Chemistry and he has also served the Division as Councilor and Chair. Three of Mitscher's former students will make presentations in the symposium in his honor. They are Daniel Flynn (Millenium), Ashok Bhattia (Abbott) and Hollis Showalter (Parke-Davis).

The Division of Medicinal Chemistry has established this award, consisting of $3,000, a scroll and travel expenses incidental to receiving the Award. The award is made biennially, in even-numbered years, at the National Medicinal Chemistry Symposium. The recipient is asked to present an Award Address on this occasion. The Award is open to any scientist here or abroad, whose research has, directly or indirectly, had a significant effect on Medicinal Chemistry. Although other types of accomplishment (such as a new research tool or a biological discovery) shall not be excluded, emphasis shall be placed on (a) Medicinal Chemistry, (b) recent contributions, and (c) scientists whose accomplishments have not already been adequately recognized in the form of other honors. Research teams shall not be excluded as sharers of the Award.

2000-2001 Predoctoral Fellowships

The ACS Division of Medicinal Chemistry announces the continuation of its Fellowship Program. Five $20,000 fellowships will be awarded , through the sponsorship of the following companies: Abbott Laboratories, Bristol-Myers Squibb, Hoechst-Marion Roussel, Parke-Davis Pharmaceutical Research and Wyeth-Ayerst Research. The awards are for predoctoral students engaged in medicinal chemistry research in a Medicinal Chemistry, Pharmaceutical Chemistry, Biochemistry, or Chemistry Department listed in the current ACS Directory of Graduate Research.

Nominations should include a complete student curriculum vitae, including education and work experience; a student bibliography, including reprints of articles; a complete project description including rationale (five-page limit) prepared by the candidate; transcripts of all post-high school work, including Graduate Record Examination scores (if available); three letters, including a nomination letter from the student's research advisor; and a letter from a university official with a commitment to cover tuition and all fees granted to other regular students.

Applicants must be U.S. citizens or permanent resident visa holders at the time of application and must have at least one year of graduate school remaining at the time an award would begin September 1, 2000. Additional information (including a complete set of guidelines) can be obtained from Dr. Annette Doherty, Institut de Recherche Jouveinal, 3-9 rue de la Loge, BP 100, 94265 Fresnes, Cedex, France, phone 33-1-41-96-7578, fax 33-1-40-96-7559, e-mail address: annette.doherty@wl.com.

All application materials for the awards are due January 15, 2000 and must be received by Dr. Doherty at the above address.

The Division of Medicinal Chemistry On-Line Employment Service

The ACSMEDI "virtual job service", located at http://wiz2.pharm.wayne.edu/employ.html and also accessible from the Division main page has been very popular. A link to the Organic Division employment site is also provided. Division members may post ads to the employment section in any of the four sections (industrial, academic, government, postdoctoral) by forwarding the text of the position announcement and any associated graphics by e-mail to Pat Woster at woster@wizard.pharm.wayne.edu.

Upcoming Meetings of Interest

4th International Symposium on Medicinal Chemistry of Neurodegenerative Diseases

January 30 - February 2, 2000

Marriott CasaMagna, Cancun, Mexico


Sunday, January 30, 2000

1-6PM - Registration
7-10PM - Opening Reception

Monday, January 31, 2000

7:50AM - Welcome
8-10:00AM - Session 1. Apoptosis in Neurons (Chair: Francesco Salituro, Vertex)

Chia-Yi Kuan (Yale University School of Medicine)
Keith Wilson (Vertex Pharmaceuticals)
George S. Robertson (Merck Research Labs)
David Anderson (Signal Pharmaceuticals, Inc.)

10:00-10:30AM - Coffee Break

10:30AM-12:30PM - Session 2. Neuronal Signaling (Chair: Anna C. Maroney, Cephalon, Inc.)

Robert Datta (Children's Hospital, Harvard Medical School)
David Park (University of Ottawa)
Anna Maroney (Cephalon, Inc.)
Robert Hudkins (Cephalon, Inc.)

5:30-6:30PM - Poster Session

6:30-7:30PM - Buffet Dinner

Monday, January 31, 2000

7:30-9:30PM - Session 3. Glutamate Mechanisms (Chair: David Horwell, Parke-Davis Pharmaceutical Research)

David Lodge (LillyResearch Laboratories) - Keynote Speaker
Roberto Pellicciari (Universita de Perugia)
Graham Durant (Cambridge Neuroscience)
Ulf Madsen (University of Copenhagen)

Tuesday, February 1, 2000

8-10:00AM - Session 4. - beta-Amyloid Inhibition (Chair: Corinne Augelli-Szafran, Parke-Davis Pharmaceutical Research)

Peter T. Lansbury, Jr. (Bringham and Womwn's Hospital and Harvard Medical School) - Keynote Speaker
Mark Findeis (Praecis Pharmaceuticals)
Claudio Soto (Serono Pharmaceutical Research Institute)
Michael G. Zagorski (Case Western Reserve University)

10:00-10:30AM - Coffee Break

10:30AM-12:30PM - Session 5. Neuroinflammation (Chair: Sheryl Hays, Institute de Recherche Jouveinal/Parke-Davis)

Edward D. Hall (Parke-Davis Pharmaceutical Research) - Keynote Speaker
Gordon Bundy (Pharmacia and Upjohn)
Jeffery S. Carter (Monsanto-Searle)
Frank Barone (SmithKline Beecham)

5:30-6:30PM - Poster Session

6:30-8:00 - Banquet

8:00-9:00PM - Symposium Keynote Speaker: Kenneth L. Davis (Mount Sinai School of Medicine)

Wednesday, February 2, 2000

8-10:00AM - Session 6. Oxidative Burden in Neurodegeneration (Chair: William Michne, AstraZeneca Research and Development)

George Perry (Case Western Reserve University)
Ashley Bush (Massachusetts General Hospital East)
M. Flint Beal (New York Presbyterian Hospital - Weill Medical College of Cornell University)
Jill Panetta (Eli Lilly & Co.)

10:00-10:30AM - Coffee Break

10:30AM-12:30PM - Session 7. Huntington's Disease (Chair: Danilo A. Tagle, National Institutes of Health)

Anne B. Young (Massachusetts General Hospital) - Keynote Speaker
Erich E. Wanker (Max-Planc-Institut fur Molekulare Genetik)
Danilo A. Tagle (National Institutes of Health)
Ira Shoulson (University of Rochester)

12:30-1:30PM - Buffet Lunch

1:30-3:30PM - Session 8. Animal Models of Neurodegeneration (Chair: Thomas N. Chase, National Institutes of Health)

Harry T. Orr (University of Minnesota) - Keynote Speaker
Larry C. Walker (Parke-Davis Pharmaceutical Research)
Li-Huei Tsai (Harvard Medical School)
Michael Ahlijanian (Pfizer Central Research)

3:30PM - Closing remarks

Visit the conference website at: http://wiz2.pharm.wayne.edu/ndd4.html.

219th American Chemical Society Meeting

San Francisco, CA

March 26-30, 2000


The final program for the Medicinal Chemistry Division is outlined below. There will be several general oral and poster sessions. The program will be available in the upcoming issues of Chemical and Engineering News as well as the Division Homepage on the World Wide Web at http://wiz2.pharm.wayne.edu.

Sunday, March 26, 2000 (Morning Session)

General Oral Papers I
Organizer: D. A. Trainor, AstraZeneca Pharmaceuticals, 1800 Concord Pike, Wilmington, DE 19850-5437

Ionotropic Glutamate Receptor Modulators
Organizers: J. Monn, Lilly Corporate Center, Eli Lilly & Co, Bldg. 48, C1109, Drop Code 510, Indianapolis, IN 46285
J. Wright, Parke-Davis Pharmaceutical Research, 2800 Plymouth Rd., Ann Arbor, MI 48105

Sunday, March 26, 2000 (Afternoon Session)

General Oral Papers II
Organizer: D. Amy Trainor

New Advances in Protein Tyrosine Phosphatase Inhibitors
Organizer: K. Shiosaki, Bldg. 300, Millennium Pharmaceuticals, One Kendall Sq., Cambridge, MA 02139

Sunday, March 26, 2000 (Evening Session)

Complete General Posters I
Organizer: D. A. Trainor

Monday, March 27, 2000 (Morning Session)

General Oral Papers III
Organizer: D. Amy Trainor

Drug Delivery Techniques in the New Millennium I
Organizer: K. Shiosaki, Bldg. 300, Millennium Pharmaceuticals, One Kendall Square, Cambridge, MA 02139

Monday, March 27, 2000 (Afternoon Session)

Drug Delivery Techniques in the New Millennium II
Presiding: K. Shiosaki, Bldg. 300, Millennium Pharmaceuticals, One Kendall Square, Cambridge, MA 02139

Tuesday, March 28, 2000 (Morning Session)

General Posters II
Organizer: D. Amy Trainor

New Prospects in Anticancer Agents for the 21st Century-Session 3, cosponsored with ORGN
Presiding: I Ojima, Department of Chemistry, State University of New York at Stony Brook, State U of New York, Stony Brook, NY 11794-3400

Tuesday, March 28, 2000 (Afternoon Session)

Case Studies of Success Stories in Drug Discovery and Development
The Alfred Burger Award in Medicinal Chemistry Address will be presented at this symposium
Organizer: B. K. Trivedi, Parke-Davis Pharmaceutical Research, 2800 Plymouth Rd, Ann Arbor, MI 48105

Wednesday, March 29, 2000 (Morning Session)

General Oral Papers IV
Organizer: D. Amy Trainor

Wednesday, March 29, 2000 (Afternoon Session)

Protein Therapeutics
Organizers: G. Ellestad, Wyeth-Ayerst Research Labs, Pearl River, NY 10965; Takushi Kaneko, Pfizer Central Research, Eastern Point Road, Groton, CT 06340

General Oral Papers V
Presiding: D. Amy Trainor

Thursday, March 30, 2000 (Morning Session)

Selective Estrogen Receptor Modulators
Organizer: J. Monn, Bldg. 48, C1109, Eli Lilly & Co, Lilly Corporate Center, Drop Code 510, Indianapolis, IN 46285

Process Research in the Pharmaceutical Industry, cosponsored with ORGN
Organizer: T. Kaneko, Pfizer Central Research, Eastern Point Rd., Groton, CT 06340

Thursday, March 30, 2000 (Afternoon Session)

Chemokine Antagonists as Anti-inflammatory and Antiviral Agents
Organizer: J. McCarthy, Eli Lilly Corporation, Lilly Corporate Center, Drop 1513, Indianapolis, IN 45285


Cosponsored Sessions

Sunday, March 26, 2000 (Morning Session)

Experimental, computational, and informatics challenges of ADME/Tox in early stage drug discovery: 1. Informatics Aspects in Early ADME/Tox,
Cosponsored with CINF, TOXI, COMP
Organizer, Presiding: Osman F. Gner, Molecular Simulations Inc., 9685 Scranton Rd, San Diego, CA 92121

Sunday, March 26, 2000 (Afternoon Session)

Experimental, computational, and informatics challenges of ADME/Tox in early stage drug discovery: 2. Computational Tools for Predictive ADME/Tox
Cosponsored with CINF, TOXI, COMP Organizer: Osman F. Gner, Molecular Simulations Inc., 9685 Scranton Rd, San Diego, CA 92121
Presiding: Kenneth M. Merz, Center for Informatics & Drug Discovery, Pharmacopeia, Inc., 2000 Cornwall Road, Monmouth Junction, NJ 08852

From Benchtop Research to Pilot-Plant Production
Cosponsored with ORGN
Organizers: L. McQuire, Chemistry Research, Novartis Pharmaceuticals Corp., 556 Morris Ave., Summit, NJ 07901-1398
M. Nafissi, Fibrogen, 225 Gateway Blvd., South San Francisco, CA 94403-3714

New Prospects in Anticancer Agents for the 21st Century I
Cosponsored with ORGN,
Organizer: I Ojima, Dept. of Chemistry, State U of New York, Stony Brook, NY 11794-3400

Monday, March 27, 2000 (Afternoon Session)

Experimental, computational, and informatics challenges of ADME/Tox in early stage drug discovery: 3. Plenary Session
Cosponsored with CINF, TOXI, COMP
Organizer, Presiding: Osman F. Gner, Molecular Simulations Inc., 9685 Scranton Rd, San Diego, CA 92121

New Prospects in Anticancer Agents for the 21st Century II
Cosponsored with ORGN
Organizer: I Ojima, Dept. of Chemistry, State U of New York, Stony Brook, NY 11794-3400

Wednesday, March 29, 2000 (Morning Session)

Organic Chemistry for the 21st Century: Emerging Pharmaceuticals and Agrochemicals I,
Cosponsored with ORGN
Organizer: V. Snieckus, Queen's University, Kingston, ON K7L 3N6 Canada
Presiding: Thomas M. Stevenson, DuPont Agricultural Products, Stine-Haskell Research Center, P.O. Box 30, Newark, DE 19714

:

Wednesday, March 29, 2000 (Afternoon Session)

Organic Chemistry for the 21st Century: Emerging Pharmaceuticals and Agrochemicals II
Cosponsored with ORGN
Organizer: V Snieckus, Queen's University, Kingston, ON K7L 3N6 Canada
Presiding: Thomas M. Stevenson, DuPont Agricultural Products, Stine-Haskell Research Center, P.O. Box 30, Newark, DE 19714

MARM 2000 Call for Papers

The 33rd Middle Atlantic Regional Meeting (MARM) will be held at the Clayton Hall Conference Center at the University of Delaware in Newark, Delaware, May 15-17, 2000. The programming theme for this meeting will be "Accelerating Drug Discovery and Development" with a plenary session featuring lectures by Paul Anderson (DuPont Pharmaceuticals), Jan Lundberg (AstraZeneca), and Chris Cimarusti (Bristol-Myers Squibb). Symposia and general sessions are planned for the following areas of chemistry: organic, medicinal, bioscience, analytical, inorganic, physical, polymer, agrochemical, and computational. A full listing of symposia along with invited speakers appears on our website at http://www.dca.net/marm2000. Abstracts on a standard ACS form should be submitted to the Program Chair MARM 2000, Dr. David K. Lloyd, DuPont Pharmaceuticals Co., PO Box 80353, Wilmington, DE 19880-0353, by February 18, with preference for oral or poster presentation indicated along with instructions in the event that preference cannot be accommodated.

Residential School on Medicinal Chemistry

June 12-16, 2000, Drew University, Madison, NJ. Contact Professor William J. Houlihan, Charles A. Dana Research Institute, Hall of Sciences, Room 331, Drew University, Madison NJ 07940, USA. Tel: 973-408-3787, Fax 973-408-3504, E-mail: resmed@drew.edu. Complete program and registration form can be found on the School website at http://www.depts.drew.edu/resmed.

2000 National Medicinal Chemistry Symposium

June 13-17, 2000

Westin Crown Center, Kansas City

Phone: 913/897-8522

FAX: 913/897-8540


SPONSORED BY

Division of Medicinal Chemistry,
American Chemical Society

HOSTED BY

Department of Medicinal Chemistry,
University of Kansas

GENERAL CHAIR

Gary L. Grunewald, University of Kansas
E-mail: ggrunewald@ukans.edu

PROGRAM CO-CHAIRS

Michael Rafferty, Parke Davis
E-mail: raffe01@aa.wl.com

Daniel Flynn, Amgen
E-mail: dflynn@amgen.com

AWARD ADDRESS

Recipient of the 2000 Division of Medicinal Chemistry Award - Lester A. Mitscher, Ph.D.


SYMPOSIUM TOPICS

Tuesday Evening, June 13, 2000

7:00 pm - Opening Reception

Wednesday Morning, June 14, 2000

ATP-Competitive Kinase Inhibitors: Coming of Age Clinically
Alexander J. Bridges, Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Corporation, Chair

8:00 am Welcome - Gary L. Grunewald, General Chair and Daryle H. Busch, ACS President
8:15 am - Introductions, Alexander J. Bridges
8:20 am - Andrew J. Barker (AstraZeneca) "ATP Competitive Inhibitors of Kinases in the Treatment of Disease: ZD 1839"
9:05 am - Robert L. Hudkins (Cephalon Inc.) "CEP-1347 (KT-7515) as a Potential Treatment for Parkinson's Disease"
9:50 am - Refreshment Break
10:15 am - Michael Su (Vertex Pharmaceuticals Inc.) "Drug Design of VX-745: A p38 MAP Kinase Inhibitor"
11:00 am - Alexander Bridges (Parke-Davis Pharmaceutical Research) "Cl-1033: An Irreversible Inhibitor of the ErbB Family of Oncogenes"

Wednesday Afternoon, June 14, 2000

Development of Selective Protein Tyrosine Phosphatase Inhibitors
Zhong-Yin Zhang, Albert Einstein College of Medicine, Chair

1:15 pm - Introductions, Zhong-Yin Zhang
1:20 pm - Zhong-Yin Zhang (Albert Einstein College of Medicine) "Molecular Basis of Substrate and Inhibitor Specificity for Protein Tyrosine Phosphatases"
2:00 pm - Terrence R. Burke, Jr. (National Cancer Institute) "Protein-Tyrosine Phosphatase Inhibitors: From Peptides to Small Molecules"
2:40 pm - Refreshment Break
3:05 pm - Jay Wrobel (Wyeth-Ayerst Research) "Novel, Orally Active PTP1B Inhibitors with Antihyperglycemic Activity"
3:45 pm - Rebecca A. Urbanek (AstraZeneca Pharmaceuticals) "Potent Reversible Inhibitors of Protein Tyrosine Phosphatase CD45"
4:10 pm - John S. Lazo (University of Pittsburgh Medical School) "Targeted Library of Dual Specificity Phosphatase Inhibitors"

Wednesday Evening, June 14, 2000

5:00 pm - Poster Session and Reception

Thursday Morning, June 15, 2000

New Serine and Cysteine Reversible Protease Inhibitors
Daniel F. Veber, SmithKline Beecham, Chair

8:15 am - Introductions, Daniel F. Veber
8:20 am - Daniel F. Veber (SmithKline Beecham Pharmaceuticals) "Advances in the Development of Cathepsin K Inhibitors for Osteoporosis"
8:55 am - Catherine Kostlan (Parke-Davis Pharmaceutical Research) "The Design of Novel Inhibitors of Caspase-1 (Interleukin-1b Converting Enzymes)"
9:30 am - Refreshment Break
10:00 am - Victor G. Matassa (IRBM) "Advances in the Development of HCV NS3 Protease Inhibitors"
10:35 am - Phillip E. Sanderson (Merck) "Design of Orally Bioavailable Thrombin Inhibitors"
11:10 am - Ruth Wexler (DuPont Pharmaceutical Company) "The Design and Synthesis of Orally Bioavailable Noncovalent Factor Xa Inhibitors"

Thursday Afternoon, June 15, 2000

1:30 pm - Afternoon Tour of your Choice
7:00 pm - Optional "A Taste of Kansas City" Barbecue, Blues and Jazz Pub Crawl

Friday Morning, June 16, 2000

Amyloid Precursor Protein Processing/Secretases
James E. Audia, Eli Lilly and Company, Chair

8:15 am - Introductions, James E. Audia
8:20 am - James E. Audia, Eli Lilly and Company "In Vivo Reduction of Ab by Novel Small Molecule Inhibitors"
9:05 am - Michael S. Wolfe (Brigham and Women's Hospital and Harvard University) "Molecular Probes for Alzheimer's g-Secretase"
9:50 am - Refreshment Break
10:15 am - Richard E. Olsen (DuPont Pharmaceuticals Company) "Non-Peptide Inhibitors of Ab Production"
11:00 am - Ben Munoz (SIBIA) "Design, Synthesis and Evaluation of Modulators of APP Processing"

Friday Afternoon, June 16, 2000

Division of Medicinal Chemistry Award Symposium Honoring Lester A. Mitscher

1:15 pm - Introductions, Gary L. Grunewald
1:20 pm - Daniel L. Flynn (Millennium Pharmaceuticals) "Integration of Synthesis with Purification: Overview of Strategies for Parallel Array Medicinal Chemistry"
2:05 pm - Ashok Bhatia (Abbott Laboratories)
2:50 pm - Refreshment Break
3:20 pm - Hollis Showwalter (Parke-Davis Pharmaceutical Research) "Recent Progress in the Large Scale Synthesis of Macrolide Antibiotics" "Tyrosine Kinase Inhibition as a Therapeutic Strategy to Regulate Tumor Angiogenesis"
4:05 pm - Award Presentation - Jane Aldrich, Chair, Division of Medicinal Chemistry
4:15 pm - Lester A. Mitscher (University of Kansas) "Medicinal Chemical Approaches to Solving the Multiple Antibiotic Resistance Problem"

Friday Evening, June 16, 2000

5:00-7:00 pm - Poster Session and Reception

Saturday Morning, June 17, 2000

Methods and Applications of Solution Phase Combinatorial Chemistry
Dale L. Boger, The Scripps Research Institute, Chair

8:15 am - Introductions - Dale L. Boger
8:20 am - Michael A. Walters (Parke-Davis Pharmaceutical Research) "Simple Reactions, Complex Products: New Templates for Exploratory Libraries"
9:05 am - David E. Bergbreiter (Texas A&M University) "Using Soluble Polymer Supports in Organic Catalysis and Synthesis"
9:50 am - Refreshment Break
10:15 am - Kim D. Janda (The Scripps Research Institute) "The Application of Soluble and Insoluble Supports in Organic Synthesis"
11:00 am - Dennis P. Curran (University of Pittsburgh) "New Concepts and Techniques for Fluorous Synthesis"

Saturday Afternoon, June 17, 2000

Highlights in Organic Synthesis
Gunda Georg, University of Kansas, Chair

1:15 pm - Introductions, Gunda Georg
1:20 pm - Dale L. Boger (The Scripps Research Institute) "Natural Products and Nature's Lessons"
2:05 pm - Robert Grubbs (California Institute of Technology) "Olefin Metathesis Catalysts for the Rapid Synthesis of Olefins"
2:50 pm - Refreshment Break
3:15 pm - Ivar Ugi (Technical University of Munich) "The Variability of Multicomponent Reactions (MCRs) and the Increasing Number of Their Educts"
4:00 pm - Larry E. Overman (University of California, Irvine) "New Strategies for Ring Construction. Applications in Natural Products Total Synthesis"
4:45 pm - Closing Remarks

Saturday Evening, June 17, 2000

6:30 pm - Banquet Reception
7:30 - Symposium Banquet, Westin Crown Center (Featuring entertainment by The New Dawn Dancers of Haskell Indian Nations University from Lawrence, KS)

FURTHER INFORMATION

www.pharm.ukans.edu/nmcs
E-mail: phicks@ukans.edu
phone: 913/897-8522
fax: 913/897-8540

Designing Drugs with Optimal In Vivo Activity after Oral Administration

June 19&20, 2000

A Special Topics course of the Residential School on Medicinal Chemistry, Forrestal Conference Center, Princeton NJ. Contact Professor William J. Houlihan, Charles A. Dana Research Institute, Hall of Sciences, Room 331, Drew University, Madison, NJ 07940, USA. Tel. 973-408-3787, Fax 973-408-3504, E-mail: resmed@drew.edu. Complete program and registration form can be found on the School website at http://www.depts.drew.edu/resmed.

Designing Drugs to Minimize or Maximize Exposure to the Brain

June 22&23, 2000

A Special Topics course of the Residential School on Medicinal Chemistry, Forrestal Conference Center, Princeton NJ. Contact Professor William J. Houlihan, Charles A. Dana Research Institute, Hall of Sciences, Room 331, Drew University, Madison, NJ 07940, USA. Tel. 973-408-3787, Fax 973-408-3504, E-mail: resmed@drew.edu. Complete program and registration form can be found on the School website at http://www.depts.drew.edu/resmed.

220th American Chemical Society Meeting

August 20-24, 2000

Washington, DC

The draft program for the 220th American Chemical Society Meeting to be held in Washington, D.C. is as follows:

Sun AM - RNA as a Drug Target - J. Schwab
Sun PM - Protein-Protein Interactions - G. Ellestad
Mon AM - Integrins Past Present and Future - Lam/Trivedi/Ruminski
Mon PM - Integrins Past Present and Future - Lam/Trivedi/Ruminski
Tues AM - P2 Nucleotide Receptors - K. Jacobsen
Tues PM - Chemoprevention - P. Woster
Wed AM - Dual Acting Drugs - R. Silverman
Wed PM - Functionating Novel Targets - K. Shiosaki
Thurs AM - Witiak Memorial Symposium - D. Rotella
Thurs PM - Cardiovascular - B.K. Trivedi

Poster and general oral sessions will also be presented at the usual times. For additional information, contact the ACS website at http://www.acs.org/meetings.

XVI International Symposium on Medicinal Chemistry

Bologna, Italy

September, 2000

Conference WWW Site: http://www.scfarm.unibo.it/bo2000


PRELIMINARY PROGRAMME OVERVIEW

Monday,
September 18, 2000

15.00-17.00 Registration
17.00-17.30 Opening - Nauta Award
17.30-18.30 Inaugural Lecture: Rational drug design. What will it look like in the 21st Century? D. Rich (USA)
18.30-20.30 Welcome Cocktail Party

Tuesday,
September 19, 2000

8.00-9.00 Registration
9.00-9.45 Plenary Lecture: Pharmacotherapy of the major cardiovascular diseases R. R. Ruffolo (USA)
10.00-12.25 Parallel Sessions:

Antihypertensive Agents G. Gaviraghi (Italy), J. A. Robl (USA), J. D. Elliot (USA)
The Impact of Organic Chemistry on Drug Discovery D. L. Boger (USA), C. Chatgilialoglu (Italy), A. K. Gosh (USA), J. Delgado Martin (Spain)
Antiinfective Agents S. G. Vasudevan (Australia), I. Hayakawa (Japan), M. Ishiguro (Japan), C. Y. Hong (Korea)

10.30-11.00 Coffee Break
12.45-14.00 Lunch Break
14.00-16.25 Parallel Sessions:

Hypolipidaemics/Antiatherosclerotics P. Martres (UK), C. Leach (UK), C. Tarby (USA)
Anticancer Agents S. Neidle (UK), W. A. Denny (New Zealand), C. Hlne (France), P. Cozzi (Italy)
New Paradigms in Receptorology M. J. Smit (The Netherlands), H. Weinstein (USA), A. P. IJzerman (The Netherlands), S. B. Liggett (USA)

15.00-15.30 Coffee Break
16.30-18.00 Poster Session
21.00 Concert

Wednesday,
September 20, 2000

9.00-9.45 Plenary Lecture: New developments in antiviral chemotherapy E. De Clerq (Belgium)
10.00-12.25 Parallel Sessions:

Ligands for P1 and P2 Purinergic Receptors K. A. Jacobson (USA), E. Ongini (Italy), C. E. Mueller (Germany), L. J. S. Knutsen (UK)
Antiviral Agents V. G. Matassa (Italy), S. K. Erickson-Vittanen (USA), D. M. Lambert (USA), C. J. Maring (USA)
Natural Products C. Khosla (USA), M. D. Lee (USA), W. Fenical (USA), K. Hostettmann (Switzerland)

10.30-11.00 Coffee Break
12.45-14.00 Lunch Break
14.00-18.00 Excursions

Thursday,
September 21, 2000

9.00-16.25 Parallel Sessions:

Neurodegenerative Diseases E. Giacobini (Switzerland), W. Greenlee (USA), P. T. Lansbury (USA), P. Jenner (UK), R. M. Nitsch (Switzerland), I. McDonald (USA), J. A. Kemp (Switzerland), L. Schnell (Switzerland)
Ligands for Glutamate and GABA Receptors R. Pellicciari (Italy), A. P. Kozikowski (USA), F. Gasparini (Switzerland), J. A. Monn (USA), A. M. MacLeod (UK), W. Froestl (Switzerland), P. L. Ornstein (USA), J. Wright (USA)
Pain and Inflammation P. Prasit (Canada), A. Mantovani (Italy), C. Farina (Italy), G. De Nanteuil (France), R. Di Fabio (Italy), M. Nobbs (UK), G. M. Dondio (Italy), G. Ronsisvalle (Italy)

10.00-10.30 Coffee Break
12.30-14.00 Lunch Break
15.00-15.30 Coffee Break
16.30-18.00 Poster Session
20.00-23.00 Gala Dinner

Friday,
September 22, 2000

9.00-9.45 Plenary Lecture: The continuing evolution of the drug discovery process in the pharmaceutical industry E. Ratti (Italy)
9.50-10.20 Coffee Break
10.25-10.40 Short Communications: Poster lectures
10.45-11.00 Short Communications: Poster lectures
11.05-11.20 Short Communications: Poster lectures
11.25-12.45 Poster Session
12.45-14.00 Lunch Break
14.00-16.25 Parallel Sessions:

Polyamines as Templates for Transmitter Receptor Ligands P. Krogsgaard-Larsen (Denmark), G. Hesse (Switzerland), M. G. Bixel (Germany), P. N. R. Usherwood (UK)
New Technologies C. Rawlings (UK), Y. C. Martin (USA), M. Bradley (UK), M. Shapiro (USA)
Pharmacokinetic Lead Optimisation J. Dressman (Germany), S. Kraemer (UK), B. Testa (Switzerland), M. Cronin (UK)

15.00-15.30 Coffee Break
16.30 Closing


Scientific Advisory Board:

D. Buckle (UK)
A. Cordi (France)
J. Frigola (Spain)
A. K. Ganguly (USA)
W. Froestl (Switzerland)
H. D. Hltje (Germany)
A. P. Kozikowski (USA)
P. Krogsgaard-Larsen (Denmark)
K. Jakobson (USA)
R. Imhof (Switzerland)
A. Lipkowski (Poland)
P. Ornstein (USA)
P. Portoghese (USA)
J. Poupaert (Belgium)
D. Rees (UK)
R. R. Ruffolo (USA)
F. Sanz (Spain)

Scientific Committee:

F. Dall'Acqua, chairman (Italy)
C. Melchiorre, co-chairman (Italy)
E. Aiello (Italy)
P. G. Baraldi (Italy)
D. Donati (Italy)
A. Gasco (Italy)
F. Gualtieri (Italy)
E. Kyburz (Switzerland)
A. Leonardi (Italy)
B. Macchia (Italy)
N. Mongelli (Italy)
E. Novellino (Italy)
R. Pellicciari (Italy)
G. Tarzia (Italy)
B. Testa (Switzerland)
H. Timmerman (The Netherlands) MC-ACS
A. M. Doherty (USA)
T. M. Perun (USA)

AFMC

N. Koga (Japan)

EFMC

J.-C. Mller (France)

Poster Review Committee

V. Tortorella, chairman (Bari)
A. Carotti (Bari)
F. Sparatore (Genova)
V. Tumiatti (Bologna)

Proceedings Editor

G. Ronsisvalle (Catania)

Organising Committee

C. Melchiorre, chairman (Bologna)
A. Minarini, secretary (Bologna)
A. Chiarini (Bologna)
R. Gatti (Bologna)
L. Mosti (Genova)
M. Rambaldi (Bologna)
M. Recanatini (Bologna)

Pacifichem 2000

December 14-19, 2000

Honolulu, Hawaii

The International Chemical Congress of Pacific Basin Societies, Pacifichem 2000, is established to disseminate recent research results in the chemical sciences among chemists of the Pacific Rim countries, thereby fostering industrial development, improve local and global environments, and the material well-being of their peoples. The Congress is cosponsored by the ACS, The Chemical Society of Japan, Canadian Society for Chemistry, New Zealand Institute of Chemistry, and the Royal Australian Chemical Institute. Over 179 symposia have already been accepted for presentation. Most symposium organizers will accept contributed papers in either oral or poster format. The official abstract form will be released in 1999 with an anticipated deadline of April 1, 2000. Further information can be obtained from the Congress Secretariat, c/o American Chemical Society, 1155 16th St. N.W., Washington, D.C. 20036, E-mail: pacifichem@acs.org, FAX: 202-872-6128.

Schedule of Upcoming ACS National Meetings

219th National Meeting, Spring 2000, March 26-30, San Francisco, CA
220th National Meeting, Fall 2000, August 20-24, Washington, D.C.
221st National Meeting, Spring 2001, April 1-5, San Diego, CA
222nd National Meeting, Fall, 2001, August 26-30, Chicago, IL

Division of Medicinal Chemistry Travel Grants

The Division of Medicinal Chemistry makes available 14 grants annually of $600 each to aid young chemists in presenting papers at the ACS National Meetings.

The applicant must be an ACS member (student or affiliate) and not have previously been the recipient of this award. Each university department can have only one awardee.

In order of priority, the following criteria will be used for selection of awards: Graduate Students, Postdoctoral Fellow, Individual with less than five years post-Ph.D. experience. Scientific merit of paper to be presented will also be considered.

Send applications to Amy Trainor, AstraZeneca Pharmaceuticals, 1800 Concord Pike. Wilmington, DE 19850-5437, USA. Applications are due on the same day as the deadline for poster abstract submittals.

Awardees will be notified of the granting of such an award in sufficient time so that the awardee can pre-register for the meeting. The awards will be made at the Sunday evening business meeting of the Division.

APPLICATION FORM TO BE SUBMITTED WITH ABSTRACT

1. Name of Applicant for Travel Grant ____________________________________.
2. Degree __________ Year Obtained:___________________
3. Present Institution:______________________________________
4. Department:________________________________________________________
5. Work to be reported was (check one or more):

a. Ph.D. Thesis ___________
b. M.S. Thesis ___________
c. Postdoctoral Fellowship ___________
d. Supported by:
1. Grant___________
2. Department ___________
3. Other__________________________________

General ACS Information


New Web Site Makes Searching and Ordering ACS Books Easy and Less Expensive

ACS members can now order ACS Books online at a 25% discount and easily search for titles by author, title, keyword, subject, and symposia number simply by visiting http://www.oup-usa.org/acs.

The ACS Books home page immediately allows users to search the entire list of ACS Books by author, title, or keyword simply by clicking on the ACS logo. Or users can click on one of twelve ACS subject classifications and search for titles by subject. ACS symposia titles can be found by series number by clicking on Find a Book, then clicking on General Catalog: Series, then ACS Symposium Series. Users then have to click on Back and search for the book by title or author to purchase at the 25% discount. On symposia titles for which members qualify for a 40% discount user is a member of the sponsoring division, orders will have to placed using a discount coupon in the division newsletter or emailed to: ixb@oup-usa.org.

Current additional features include full table of contents for most titles and an easy-to-use shopping basket for ordering. Future enhancements will include the ability to search and order all OUP chemistry and related titles at the 25% discount and an ACS Books Listserv, so subscribers can quickly learn about just published titles and special offers.

For more information about the ACS Books web site contact Mike Seiden at Oxford University Press, 198 Madison Avenue, NY, NY 10016; phone 212-726-6070 or email mes@oup-usa.org.


Learning Module on Copyright

At its open meeting on August 23 and at the Council meeting in New Orleans, the Joint Board/Council Committee on Copyrights announced that its "Learning Module: What Chemists Need to Know about Copyright," is complete and posted on the ACS's Publications Web site: http://pubs.acs.org (click on the Copyright and Permissions button, then click on any of the journal titles for even more copyright information and forms). The module was developed by a Task Force of the committee over the last four years to meet the needs for a college level teaching module. Text can be transferred to transparencies for classroom use and there are test questions with answers and scenarios for discussion. It is useful, easy to read, and can be accessed and used by all. The information pamphlet, "Are You Up to Date on ACS Copyright Issues," is also part of the module; it was revised and updated to accommodate recent changes to the U.S. Copyright Act. A FAQ (frequently asked questions) from the U.S. Copyright Office is part of the learning module as well.

At the ACS meeting in New Orleans, the Copyright Committee was discharged with thanks. The good news is that its functions will now be under the purview of the Joint Board/Council Committee on Publications (JBCCP). For those who will be at the ACS meeting in Washington, DC in August 2000, the Division of Chemical Information will be sponsoring a symposium on the "Copyright Implications of Electronic Information."


Calling All Chemists-Senior Professionals and Graduate Students: Apply for one of the two ACS Congressional Fellowships

Work in the Congress using your scientific and technical expertise
Gain first-hand knowledge of the legislative branch

Contact:

Congressional Fellowship Program
Office of Legislative and Government Affairs
American Chemical Society
1155 16th Street, NW
Washington, DC 20036
202/452-8917
Internet: http://www.acs.org/government/publications.congressional.html
E-mail: congfellow@acs.org.


ACS Launches New Web-Based Legislative Action Center

In an effort to promote ACS member involvement and to increase the Society's impact on public policy, the ACS has just added a Legislative Action Center to its Government Affairs web site, located at http://www.legislators.com/chemical/. ACS recently sent an e-mail to ACS members, whose e-mails have been identified, encouraging them to use this center. The new center allows ACS members to identify their federal legislators, learn about the legislative process and key issues, and send letters or e-mail messages to Congress.

The Legislative Action Center comes in response to requests from ACS members to increase the Society's impact on Capitol Hill and to decrease the time it takes to communicate with policymakers. The Center also will be the essential tool for members participating in the Society's Legislative Action Network - a web-based grassroots program for updating ACS members on federal issues and facilitating contact with members of Congress. Using this interactive web site, Legislative Action Network participants now will be able to respond to timely legislative action alerts within minutes, alerting members of Congress to the concerns of ACS members before votes on R&D, education, and other key issues.

"The Action Center essentially will be a one-stop shop for all members to learn about ACS priority issues, profile their Representative and two Senators, and, if desired, send a message simultaneously to all three," said David Schutt, Assistant Director of the Office of Legislative and Government Affairs. "We hope those members not already participating in our grassroots networks will sign-up for the Legislative Action Network and take advantage of this first-rate system." Network participants also will receive monthly legislative bulletins via e-mail, to keep current on science education, R&D funding, the environment and other priority issues.

To participate in the Legislative Action Network, sign up on-line at http://www.acs.org/government/gcy/networks.html or send your name, e-mail, member #, and home address to grassroots@acs.org.


Liability Insurance for Chemical Professionals

A custom-designed group professional liability insurance policy for consultants who are Chemists and Chemical Engineers. Provides coverage for defense expenses and settlement with a host of special benefits and options.

For more information, visit our web site at www.acs.org/insurance or contact the plan administrator at 1-800-445-3393.

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