The Division of Medicinal Chemistry

Fall 1997 Newsletter

Annette M. Doherty - Secretary

New Divisional Officers

Amy Trainor was elected Vice-Chair of the Division of Medicinal Chemistry. Her term begins in January, 1998 and includes chairmanship of the Long Range Planning Committee.

Elected to the position of Councilor for a three-year term (1998-2000) was James McCarthy. His term begins in January, 1998.

Leslie G. Humber will continue to serve as Treasurer in 1998. Annette M. Doherty will serve as Secretary of the Division and Kenneth L. Kirk will be Chair. Leroy B. Townsend, Michael F. Rafferty and Dale L. Boger will continue to serve as Councilors and Thomas J. Perun will be the Past Chair.

215th American Chemical Society Meeting
Dallas Texas, March 29-April 2, 1998

The program for the Medicinal Chemistry Division is outlined below. In addition to the listed symposia, there will be an Awards Session on Tuesday Morning.

The preliminary program will be available in the February 2 issue of C&E News and the final program will be in the March 2 issue. It will also be on the Division's Homepage located at http://wizard.pharm.wayne.edu.

Dallas, Spring 1998 Program
Symposium Title (Organizer/Chair)

Sun AM General oral papers (A. Doherty/D. Leonard)
Sun PM General oral papers (A. Doherty/B.K. Trivedi)
Sun Eve Poster Session (A. Doherty/J. Wright)
Mon AM Adenosine receptors as targets for Drug Discovery (K. Cooper/P. McGuirk)
Mon PM Protein Prenylation (K. D. Janda/R. Gibbs)
Tues AM Awards Symposium (A. Doherty)
Tues PM Cytochrome P450 and Drug Design (P. Woster)
Wed AM Kinase Inhibitors (K. Cooper/R. Wexler)
Wed PM Coagulation (R. Wexler)
Wed All Poster Session (A. Doherty/Y. Song)
Thurs AM Angiogenesis (K. Cooper/M. Moyer)
Thurs PM Amyloid Inhibition (M. Rafferty)

216th American Chemical Society Meeting
Boston, Massachusetts, August 23-27, 1998

You are invited to submit an abstract for the Boston meeting. The deadline for abstracts is April 20, 1998. The short (150 word) abstract, typed on the standard ACS form should be mailed to the Secretary at the address on p.1. Abstract forms may be obtained from the ACS office by calling (800) 227-5558 (press 9, then 4). If more convenient, we will also accept original copy on the form from the ACS website located at http://www.acs.org/meetings/abstract/abinfo.html. Faxed abstracts are not acceptable. A 1,000 word expanded abstract or equivalent supporting documentation is required for oral presentations. This additional information will be used to help select the oral papers from the many requests.

The following symposia are being organized:

Boston, Fall 1998 Program
Symposium Title (Organizer/Chair)

Sun AM General oral papers (A. Doherty)
Sun PM General oral papers (A. Doherty)
Sun PM MS in Drug Discovery Research (S.Hays/J. Loo)
Sun EVE Poster Session (A. Doherty)
Mon AM Urogenital Diseases (K. Cooper/TBA)
Mon PM Combinatorial Biosynthesis (K. Janda, K. Shiosaki/TBA)
Tues AM Awards Symposium (A. Doherty)
Tues PM Pain (S. Hays, K. Shiosaki/D. Wustrow, S. Hays)
Wed AM Malaria Therapies (J. Ellman, TBA)
Wed PM Viral Hepatitis (K. Shiosaki, TBA)
Wed All Poster Session (A. Doherty)
Thurs AM Retinoids and Cancer (W. Brouillette, TBA)
Thurs PM New Targets for Treatment of Vascular Disease/Diabetes PPARS (D. Flynn, T. Willson/TBA)

Note that awards take place on Tuesday AM with talks from fellowship awardees.

Suggestions for symposia at future meetings are invited from the Division members. Well thought-out proposals with possible speakers and topics should be sent to the Division Secretary for discussion at the Divisional Long Range Planning Committee meetings held twice a year at the national meetings.

In order to provide more thematic programs at ACS National meetings, a list of Focal Areas has been selected by the ACS Meetings Department. For the Dallas meeting, these include: catalysis; photocatalytic (COLL); petroleum chemistry; environmental issues (including chemistry and the oceans); entrepreneurship and technology transfer; women and minorities in chemistry; computational chemistry and molecular modeling; biocatalysis, bioactive agents, biomimetics, and pharmaceuticals; materials, (including electronics, surface science); and robotics and lab automation.

Division members are encouraged to submit papers in these topical areas. If enough suitable oral papers to fill a session are received, it will be designated by topic in the program.

1998-1999 Predoctoral Fellowships

The ACS Division of Medicinal Chemistry announces the continuation of its Fellowship program. Five $20,000 fellowships will be awarded in 1998, through the sponsorship of the following companies: Abbott Laboratories, Bristol-Myers Squibb, Hoechst-Marion Roussel, Parke-Davis Pharmaceutical Research, and Wyeth-Ayerst Research. The awards are for predoctoral students engaged in medicinal chemistry research in a Medicinal Chemistry, Pharmaceutical Chemistry, Biochemistry, or Chemistry department listed in the current ACS Directory of Graduate Research.

Nominations should include a complete student curriculum vitae, including education and work experience; a student bibliography, including reprints of articles; a complete project description including rationale (five-page limit) prepared by the candidate; transcripts of all post-high school work, including Graduate Record Examination scores (if available); three letters, including a nomination letter from the student's research advisor; and a letter from a university official with a commitment to cover tuition and all fees granted to other regular graduate students.

Applicants must be U.S. citizens or permanent resident visa holders at the time of application and must have at least one year of graduate school remaining at the time an award would begin September 1, 1998. Additional information (including a complete set of guidelines) can be obtained from Dr. Thomas J. Perun, Abbott Laboratories, Pharmaceutical Discovery, Dept 467, Building R-8, North Chicago, IL, 60064-4004, Phone (847) 937-8622; fax (847) 938-2258; e-mail: perunt@abbott.com.

All application materials for the awards are due on December 31, 1997 and must be received by the Secretary, Dr. Annette Doherty, Parke-Davis 2800 Plymouth, Ann Arbor, MI 48105.

National Medicinal Chemistry Symposia

The 1998 National Medicinal Chemistry Symposium will be held at the Virginia Commonwealth University in Richmond on June 13-18, 1998. Professor Donald Abraham will be the General Chair and Dr. Thomas Perun will be the Program Chair. The program will include sessions on the following topics: Drug Metabolism in Drug Design , Structure-Based Drug Design, Prodrugs and Drug Targeting, Carbohydrate Mimetics, Chemokines, p53 as a Drug Target, and Molecular Modeling in the 21st Century. There will also be an Awards session and a one-day workshop on Molecular Modeling. For more information, visit the Symposium home page located at http://www.phc.vcu.edu/26thNMCS.

The 2000 National Medicinal Chemistry Symposium will be held at the University of Kansas, and will be chaired by Professor Gary Grunewald. Program Chairs will be Drs. Michael Rafferty and Dan Flynn.

Other Meetings of Interest

Residential School on Medicinal Chemistry, June 8-12, 1998, Madison, New Jersey. Contact Professor William J. Houlihan, C.A. Dana Research Institute, Drew University, Hall of Sciences, Rm 331, Madison, New Jersey, 07940, USA. Tel: 973-408-3633, Fax: 973-408-3504, e-mail: resmed@drew.edu. Complete program and registration form can be found on the school web site at http://daniel.drew.edu/~resmed.

XIV International Conference on Phosphorus Chemistry, July 12-17, 1998, Cincinatti, Ohio. Contact Dr. Frank H. Ebetino, Procter and Gamble Pharmaceuticals, Health Care Research Center, P.O. Box 8006, Mason, OH 45040-8005, phone: 513/622-3630, fax: 513/622-1195, e-mail: ebetino.fh@pg.com. Program and registration information can be found at http://www.usc.edu/dept/chemistry/ICPC14/index.html.

XVth International Symposium on Medicinal Chemistry, September 6-10, 1998, Edinburgh, Scotland. Contact Dr. John Gibson, RSC Tel: 44-171-437-8656, Fax: 44-171-734-1227, E-Mail: conferences@rsc.org.

Schedule of Major Meetings of the American Chemical Society

215th Spring 1998 March 29-April 2 Dallas, TX
216th Fall 1998 August 23-27 Boston, MA
217th Spring 1999 March 21-25 Anaheim, CA
218th Fall 1999 August 22-27 New Orleans, LA
219th Spring 2000 March 26-31 Las Vegas, NV
220th Fall 2000 August 20-25 Washington, D.C.
221st Spring 2001 April 1-6 San Francisco, CA

Special for ACS Members

A special offer to the Members of the ACS Division of Medicinal Chemistry. Receive the top ranked journal Medicinal Research Reviews for a discounted rate. Under the editorship of Dr. Les Mitscher of the University of Kansas, Medicinal Research Reviews publishes timely and in-depth critical reviews of topics relating to drug research and development to which the authors have made significant contributions. More specifically, reviews published in the journal focus on:

The underlying pathophysiology of important diseases and disease vectors.
Therapeutic approaches to treatment of under-served disease areas.
The properties of molecular targets for therapeutic agents.
Important new methodologies facilitating the search for therapy.
Chemical, pharmacological, pharmacokinetic, and clinical characteristics of important drugs.
Structure-activity correlations of drug series.

More information about the journal can be found on its designated home page on the Wiley Website.

Special Discounted $115 in US/CAN/MEX $151 FOR THE REST OF THE WORLD.
Medicinal Research Reviews, ISSN 0198-6325, volume 18, 6 Issues
To Subscribe or request a sample copy, please contact John Wiley & Sons at the following locations (Please refer to promotion code MRRMC):

By e-mail: SUBINFO@wiley.com.
By Phone: (212) 850-6645
By Fax: (212) 850-8888
By Mail: N. English, 9th flr, John Wiley & Sons, 605 Third Avenue, New York, New York 10158-0012.

All orders must be prepaid by credit card or, from a US bank, by personal check, money or bank draft.

Patent Handbook Available from ACS

The American Chemical Society's Committee on Patents and Related Matters has rewritten its booklet What Every Chemist Should Know About Patents. Intended for chemists in industry, small businesses, and academe, the publication was prompted by enactment of legislation in 1995 that introduced major changes in the U.S. patent laws. What Every Chemist Should Know About Patents is an introduction to the essentials of patents and patenting procedures. The handbook presents an overview of the obtainment, use, and value of patents in an easily understood form.

Copies of What Every Chemist Should Know About Patents are available for $2.00 each. Requests, including prepayment to the American Chemical Society, should be sent to American Chemical Society, P.O. Box 57136, West End Station, Washington, DC 20037.

TRAVEL GRANTS

The Division of Medicinal Chemistry makes available 14 grants annually of $600 each to aid young chemists in presenting papers at the ACS National Meetings.

Eligibility: The applicant must be an ACS member (student or affiliate) and not have previously been the recipient of this award. Each university department can have only one awardee.

Criteria for Selection: In order of priority, the following criteria will be used for selection of awards: Graduate Student, Postdoctoral Fellow, Individual with less than five years post-Ph.D. experience. Scientific merit of paper to be presented will also be considered.

Application Procedure: Send applications to Annette Doherty, Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, 2800 Plymouth Road, P.O. Box 1047, Ann Arbor, MI 48106-1047.

Awardees will be notified of the granting of such an award in sufficient time to that the awardee can pre-register for the meeting. The awards will be made at the Tuesday evening business meeting of the Division.

APPLICATION FORM TO BE SUBMITTED WITH ABSTRACT

1. Name of Applicant for Travel Grant ____________________________________.
2. Degree __________ Year Obtained:___________________
3. Present Institution:______________________________________
4. Department:________________________________________________________
5. Work to be reported was (check one or more):

a. Ph.D. Thesis ___________
b. M.S. Thesis ___________
c. Postdoctoral Fellowship ___________
d. Supported by:
1. Grant___________
2. Department ___________
3. Other__________________________________

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