LAURENCE H. HURLEY, Howard J. Schaeffer Chair in Pharmaceutical
Sciences, College of Pharmacy, The University of Arizona,
Tucson, was born in 1944 in Birmingham, England. He received
his B.Pharm. (Honors) in 1967 from Bath University and his
Ph.D. (Medicinal Chemistry) in 1970 from Purdue University.
Dr. Hurley’s present research interests are in the areas
of design and development of antitumor agents. Over the last
twenty years, work from his laboratory has led to elucidation
of the structures of the drug–receptor complexes for
seven different groups of compounds that are potentially useful
in the treatment of cancer. In cooperation with the pharmaceutical
industry, several drugs developed with the aid of these studies
have been evaluated in phase I and II clinical trials. Most
recently, his research has centered on secondary DNA structures,
particularly G-quadruplexes as gene targets for drug design.
A first-in-class G-quadruplex-interactive compound developed
from technology and a lead compound licensed from The University
of Arizona and The University of Texas was advanced into phase
II clinical trials by Cylene Pharmaceuticals in 2007.
Dr. Hurley has been a consultant to a number of pharmaceutical
companies and is currently a Senior Editor for Journal of
Medicinal Chemistry. He is now also a member of the NCI Scientific
Board of Councilors. He is a recipient of the 1988 George
Hitchings Award in Innovative Methods in Drug Design, the
1989 Volwiler Research Achievement Award from the American
Association of College of Pharmacy. He is the recipient of
the 1992 APhA Research Achievement Award in Medicinal Chemistry
and the 1994 American Chemical Society Medicinal Chemistry
Award. In 2005 he was awarded the George & Christine Sosnovsky
Award in Cancer Therapy by the Royal Society of Chemistry,
and in 2007 he was inducted into the American Chemical Society
Medicinal Chemistry Hall of Fame. He is also the recipient
of a number of lectureships, including the 2001 Frank Rose
Memorial Lecture at the British Association for Cancer Research.
In 1996 he was awarded a D.Sc. degree from Bath University.